As part of the hyaluronic acid group of fillers, Restylane shares the same characteristics as other fillers in the group (Perlane, Belotero, and Juvederm). One description for any of these fillers will almost always describe the rest, particularly with Restylane and Perlane as they are both manufactured by the same company. Anyone interested in using one of the hyaluronic acid fillers will be comfortable with the fact that hyaluronic acid is a naturally-occurring substance in the body and will rarely lead to allergic reactions. The role of hyaluronic acid in the body is to lubricate most tissues and joints.

Which Areas Respond Well to Restylane?

Restylane and other hyaluronic acid fillers are my first choice for boosting volume in the lips and the lower eyelids. It also works for other parts of the face but results may not last long as  Artefill  or  Radiesse.

Reversing the Effects with Hyaluronidase

One of the unique characteristics of hyaluronic acid fillers is how its effects can be reversed by the enzyme hyaluronidase. This enzyme simply reverses the effects of Restylane and other hyaluronic acid fillers within days by dissolving the HA filler. The good news is that it’s rare for individuals to ask for hyaluronic acid filler reversal. Nevertheless, patients are more comfortable to opt for hyaluronic acid fillers because it’s reassuring to know that hyaluronidase can help reverse its effects if necessary.

When Not to Use Restylane

Although versatile and extremely effective, Restylane is a short-acting filler. Effects can last for 4 to 6 months while it could extend to a year in the lower eyelid area.* Anyone looking into fillers with long-lasting effects can either opt for Artefill and Radiesse. These fillers are also a good alternative if you only need small amounts of fillers. As smart shoppers, San Francisco locals may find Restylane as too expensive.

For large portions that need fillers such as sunken cheeks, Sculptra is a good choice. In addition, Restylane may not be as effective for very fine lines that require shallow injections because it can cause bluish discoloration  (also known as Tyndall effect) when injected very close to the skin. The same goes for Perlane and Juvederm. For very fine lines, Belotero is the most ideal.*

Perlane and Restylane Differences

Both Perlane and Restylane are made by Medicis and are equally effective in improving smile lines, areas around the lips, and other parts of the face.*  While both fillers are extremely similar, Restylane’s particles are more microscopic. As a result, it flows slightly better than Perlane. Nevertheless, Perlane can last longer in some areas.

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* Individual results may vary, and not guaranteed.

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