All four types of the hyaluronic acid (HA) category are remarkably similar to each other: Restylane, Juvederm, Belotero, and Perlane. Often, what is applicable to one filler also applies to the others. They are all made of hyaluronic acid, a clear gel that is naturally found in the almost all tissues of the human body. By and large, the human body recognizes HA as a substance that is one of its own. As a result, these fillers rarely result in an allergic reaction.
Alongside other hyaluronic acid fillers, Perlane works great in filling in the lower eye area, lips, and smile lines.* While the results of Perlane is not as long lasting as Artefill and Radiesse, it is frequently used in other regions of the face when a patient approves of shorter acting fillers.
Although Perlane is effective, it’s a short-acting filler and can last 8 -10 months for most volume-deficient areas. It may not give you the best bang for your buck if you need fillers for larger volume augmentation that need multiple syringes to take effect. Often, facial areas that require large volumes of fillers such as sunken cheeks will respond better to Sculptra. Since Perlane works better for deeper wrinkles (e.g. smile lines), it won’t be as effective in areas that need superficial placement of fillers such as fine lines. Amongst other hyaluronic acid fillers, Belotero is the best option for superficial injections. If other fillers (Juvederm, Restylane, and Perlane) are used for superficial lines, it can potentially lead to the Tyndall Effect where the injection site takes on a bluish hue.
The effects of hyaluronic acid fillers can be reversed with an enzyme referred to as hyaluronidase. When hyaluronidase is injected into the area treated with Perlane, the enzyme will dissolve the hyaluronic acid filler in a few days to a week. The good news is patients who want to remove hyaluronic acid fillers after injections rarely happen. In some cases, the presence of hyaluronidase makes some patients more comfortable in trying out fillers for the first time because they know that it’s possible to reverse the effects of HA fillers.
While both Perlane and Restylane are quite similar and created by the same company, they differ when it comes to their microscopic particle sizes. For this reason, many consider Perlane to last longer than Restylane, perhaps 1 to 2 months, while Restylane can be injected into finer areas of the face. However, choosing between Perlane and Restylane boils down to the preferences of the injection provider.
* Individual results may vary, and not guaranteed.